BST1 antibody

Catalog No. ABIN356331

Product Details anti-BST1 Antibody

Target: BST1 (Bone Marrow Stromal Cell Antigen 1 (BST1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This BST1 antibody is un-conjugated

Application: Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Characteristics: Synonyms: Blood Group Tn Antigen

Purification: PBS, pH 7.4 containing 0.05% Sodium Azide as preservative.

Immunogen: Asialo ovine submaxillary mucin (AOSM). Remarks: Molecular weight of antigen: Several HM weight glycoproteins. Epitope: alpha GalNacOSer/Thr.

Clone: TN218

Isotype: IgM

Application Details

Application Notes: Suitable for Immunohistochemistry and Immunocytochemistry (Frozen or Formalin-FixedParaffin-Embedded (FFPE) tissue sections and cell smears)For IHC dilute concentared antibody at 1/50-1/100, use streptavidinapprox. biotin system orpolymer system, incubate 30 minutes at room temperature. Immunofluorescence. Recommended Positive Control: Human gastrointestinal tumor.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 0.2 mg/mL

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf life: One year from despatch.

Expiry Date: 12 months

Target Details for BST1

Target: BST1 (Bone Marrow Stromal Cell Antigen 1 (BST1))

Alternative Name: CD175 (BST1 Products)

Synonyms: BST1 antibody, 114/A10 antibody, A530073F09 antibody, BP-3 antibody, Bp3 antibody, Bsta1 antibody, CD157 antibody, Ly65 antibody, bone marrow stromal cell antigen 1 antibody, BST1 antibody, Bst1 antibody

Background: Aberrant glycosylation is a hallmark of cancer cells. The blood group precursors T (Thomsen-Friedenreich) and Tn epitopes are shielded in healthy and benign-diseased tissues but uncovered in approx. 90 % of carcinomas. T and Tn glycoproteins are specific, autoimmunogenic pancarcinoma antigens. These antigens may also be found in neoplastic blood cells Fundamental chemical and physical aspects of these glycoproteins of primary carcinomas are discussed first. Tn and T epitopes are cell and tissue adhesion molecules, essential in invasion by and metastasis of carcinoma which includes adherent and proliferative phases. Immunohistochemical studies of the extent of Tn antigen expression in primary breast carcinoma demonstrate it highly significant correlation with clinicopathological tumor stages, and hence its value as a reliable prognosticator.Synonyms: Blood Group Tn Antigen